Splice was released on June 4, 2010, with a budget of approximately $30 million. Directed by Vincenzo Natali, the film explores themes of genetic engineering and ethics through the story of two scientists who create a human-animal hybrid. Despite its unique premise, the movie grossed $27.1 million worldwide, making it a modest box office disappointment compared to its budget.
However, Splice garnered a cult following due to its daring themes and disturbing twists. Its mix of science fiction and body horror gained critical praise, particularly for the ethical questions it raised about scientific responsibility and humanity’s urge to play God.
Though it didn’t achieve financial success, the film found a strong audience post-release, particularly among sci-fi horror fans, thanks to its exploration of cutting-edge, controversial scientific themes and a disturbing, original narrative. This enduring interest has kept discussions about the potential for a sequel alive for years.